OncoSupport™

 

The following medications are often used to treat patients with cancer and are currently listed in one of CredibleMed’s three TdP risk categories (category icons defined below):

Anti-cancer Medicine Anti-NauseaAntidepressants Anesthetics
AbarelixAmisulprideAmitriptylineCocaine
AbirateroneChlorpromazineAripiprazoleDroperidol
AclarubicinDolasetronCitalopramPropofol
Amsacrine (Acridinyl anisidide)DomperidoneClomipramineSevoflurane
ApalutamideDroperidolDesipramine
Arsenic trioxideGranisetronDoxepin
BendamustineMetoclopramideEscitalopram
BortezomibOndansetronFluoxetine
BosutinibPalonosetronFluvoxamine
CabozantinibPromethazineImipramine (Melipramine)
CapecitabineTropisetronMaprotiline
CeritinibMianserin
Cesium ChlorideMirtazapine
CobimetinibNortriptyline
CrizotinibParoxetine
DabrafenibSertraline
DasatinibTrazodone
DegarelixTrimipramine
EncorafenibVenlafaxine
Entrectinib
Epirubicin
Eribulin mesylate
Fluorouracil (5-FU)
Gilteritinib
Glasdegib
Inotuzumab ozogamicin
Ivosidenib
Lapatinib
Lenvatinib
Leuprolide (Leuprorelin)
Midostaurin
Necitumumab
Nilotinib
Osimertinib
Oxaliplatin
Panobinostat
Pazopanib
Ribociclib
Romidepsin
Rucaparib
Selpercatinib
Sorafenib
Sunitinib
Tamoxifen
Tipiracil/Trifluridine
Toremifene
Vandetanib
Vemurafenib
Vorinostat

Known Risk of TdP - Substantial evidence supports the conclusion that these drugs prolong the QT interval AND are clearly associated with a risk of TdP, even when taken as directed in official labeling.

Possible Risk of TdP - Substantial evidence supports the conclusion that these drugs can cause QT prolongation BUT there is insufficient evidence at this time that these drugs, when used as directed in official labeling, are associated with a risk of causing TdP.

Conditional Risk of TdP - Substantial evidence supports the conclusion that these drugs are associated with a risk of TdP BUT only under certain conditions (e.g. excessive dose, hypokalemia, congenital long QT or by causing a drug-drug interaction that results in excessive QT interval prolongation)

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