AZCERT Publications

Publications & Journal Articles.

2023

Tan MS, Heise CW, Gallo T, Tisdale JE, Woosley RL, Antonescu CC, Gephart SM, Malone DE, Relationship between a risk score for QT interval prolongation and mortality across rural and urban inpatient facilities. J Electrocardiol 2023;77:4-9.

Patel SI, Zareba W, Wendel C, Perez K, Patel I, Quan SF, Youngstedt SD, Parthasarathy S, Woosley RL, A QTc risk score in patients with obstructive sleep apnea,  Sleep Medicine,  2023 Feb 8;103:159-164, https://doi.org/10.1016/j.sleep.2023.02.005

Heise C, Woosley RL. A commentary on: A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study. PracticeUpdate website. Available at: https://www.practiceupdate.com/content/a-12-gene-pharmacogenetic-panel-to-prevent-adverse-drug-reactions/148128/65/2/1. Accessed February 15, 2023

2022

Woosley RL, Simmons J, Sefilyan EM, Atkins S, Black K, Read WA, Linking Technology to Address the Social and Medical Determinants of Health for Safe Medicines Use, J Patient Safety, 18(2): e596-e600, 2022(Online ahead of print) doi: 10.1097/PTS.0000000000000876.

Schaibley VM, Ramos IN, Woosley RL, Curry S, Hays S and Ramos S, Limited Genomics Training Among Physicians Remains a Barrier to Genomics-Based Implementation of Precision Medicine, Frontiers in Medicine, Vol 9, March 2022, doi: 10.3389/fmed.2022.757212

Gallo T, Heise CW, Woosley RL, Tisdale JE, Antonescu CC, Gephart SM and Malone DC, Clinician Satisfaction With Advanced Clinical Decision Support to Reduce the Risk of Torsades de Pointes. J Patient Saf 2022 DOI:  10.1097/PTS.0000000000000996

Gallo T, Heise CW, Woosley RL, Tisdale JF, Tan MS, Gephart SM, Antonescu CC, Malone DC, Clinician Responses to a Clinical Decision Support Advisory for High Risk of Torsades de Pointes, J Am Heart Assoc. 2022;11: e024338. DOI: 10.1161/JAHA.122.024338

Patel SI, Zareba W, LaFleur B, Couderc JP, Xia X, Woosley R, Patel IY, Combs D, Mashaqi S, Quan SF, Parthasarathy S. Markers of ventricular repolarization and overall mortality in sleep disordered breathing. Sleep Med. 2022 Jul;95:9-15. doi: 10.1016/j.sleep.2022.04.016. Epub 2022 Apr 22. PMID: 35533628

2021

Heise C., Woosley RL,  A commentary on: OncoSupport for Oncocardiology Prescribing. PracticeUpdate website. Available at: https://www.practiceupdate.com/content/oncosupport-for-oncocardiology-prescribing/123518/65/2/3. Accessed September 20, 2021

Woosley RL, Heise C. A commentary on: Anticancer Drug-Induced Life-Threatening Ventricular Arrhythmias: A World Health Organization Pharmacovigilance Study. PracticeUpdate website. Available at: https://www.practiceupdate.com/content/anti-cancer-drug-induced-life-threatening-ventricular-arrhythmias/122334/65/2/1. Accessed August 24, 2021

Woosley, RL and Woosley, RD, Chapter 12, QTdrugs and the CredibleMeds.org Website:  Clinical and Research Applications, Book Title “On the QT”, Editor John Somberg, 2021

Woosley, RL, Chapter 8, Drug-induced Torsades de pointes, Book title:  Torsades de pointes, Editor James Tisdale, Elsevier Publishing, 2021.

2020

Gress K L, Gallo T, Urits I, Geng X, Viswanath O, Kaye AD, Woosley RL. Investigating the Impact of Gadolinium-Based Contrast Agents on the Corrected QT Interval. Cureus. Aug 2020. 12(8): e9668. doi:10.7759/cureus.9668

Heise, CW, Gallo T, Curry SC and Woosley RL, Identification of populations likely to benefit from pharmacogenomic testing. Pharmacogenet Genomics. 30(5):91-95, 2020

Woosley, RL, Assisted Prescribing: Clinical Decision Support with MedSafety Scan. Trends Cardiovasc Med. 2020. Nov 10:S1050-1738(20)30146-8. doi: 10.1016/j.tcm.2020.11.002. Online ahead of print.

Woosley RL. Association of QT-Prolonging Medications With Risk of Autopsy-Defined Causes of Sudden Death. PracticeUpdate website. Available at: https://www.practiceupdate.com/content/association-of-qt-prolonging-medications-with-causes-of-sudden-death/97334/65/2/1. Accessed March 27, 2020

Woosley RL. Cardiac Complications of Chloroquine-Based Therapy. PracticeUpdate website. Available at: https://www.practiceupdate.com/content/cardiac-complications-of-chloroquine-based-therapy/98054/65/2/3. Accessed March 23, 2020

Woosley RL. Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review. PracticeUpdate website. Available at: https://www.practiceupdate.com/content/pharmacologic-treatments-for-covid-19/99209/65/2/1. Accessed April 27, 2020

Woosley RL. Clinical Efficacy of Hydroxychloroquine in Patients With Covid-19 Pneumonia Who Require Oxygen: Observational Comparative Study Using Routine Care Data. PracticeUpdate website. Available at: https://www.practiceupdate.com/content/clinical-efficacy-of-hydroxychloroquine-in-patients-with-covid-19-pneumonia-who-require-oxygen/100849/65/2/1. Accessed May 22, 2020

Woosley RL. Drug-Induced Arrhythmias: A Scientific Statement From the American Heart Association. PracticeUpdate website. Available at: https://www.practiceupdate.com/content/drug-induced-arrhythmias-a-scientific-statement-from-the-american-heart-association/106844/65/2/1. Accessed September 26, 2020

Woosley, RL, What do you have to lose taking Hydroxychloroquine for Coronovirus? Potentially your life. Op-Ed, USA Today, Published 2:15 pm, ET, April 12, 2020. https://www.usatoday.com/story/opinion/2020/04/10/what-have-lose-taking-hydroxychloroquine-coronavirus-life-column/5123478002/

2019

Gallo T, Curry SC, Padilla-Jones A, Heise CW, Ramos KS, Woosley RL, et al. A. Computerized Scoring System to Improve Assessment of Heparin-induced Thrombocytopenia Risk. J Thrombosis Haemostasis Vol. 17(2):383-388, 2018, Epub:  Dec 14. doi: 10.1111/jth.14359, PMID:  30552743. 

Woosley RD, Romero K, Heise CW, Gallo T, Tate J, Woosley RL. Summary of Torsades de Pointes (TdP) Reports Associated with Intravenous Drug Formulations Containing the Preservative Chlorobutanol. Drug Safety 2019;42:907-913, PMID: 30888625

Schwartz PJ, Woosley RL, Crotti L. When prescribing drugs, do medical doctors and healthcare professionals realize that their patient has the long QT syndrome? Eur Heart J 2019;40:3118-20, PMID: 31199477

Woosley, RL, Arrhythmogenic foods-A growing medical problem, Trends Cardiovascular Medicine 2019 Aug 24. pii: S1050-1738(19)30116-1. doi: 10.1016/j.tcm.2019.08.007. [Epub ahead of print] Review.  PMID:  31477495 

Woosley, RL and Schwartz, PJ, Chapter 10: Drug-induced Long QT Syndrome and Torsades de Pointes in Cardiac Repolarization:  Basic Science and Clinical Management, Nabil El-Sherif editor, Springer Publishing, New York,  2019  ISBN: 978-3-030-22671-8

2018

Woosley RL, Black K, Heise CW, Romero K. CredibleMeds.org: What does it offer? Trends Cardiovasc Med 2018;28(2):94-9.

Woosley R. Estimated Cardiac Risk Associated With Macrolides and Fluoroquinolones Decreases Substantially When Adjusting for Patient Characteristics and Comorbidities. PracticeUpdate website. Available at: http://www.practiceupdate.com/content/cardiac-risk-associated-with-macrolides-and-fluoroquinolones-decreases-when-adjusting-for-patient-characteristics-and-comorbidities/67444/65/2/1. Accessed July 17, 2018

Woosley RL, Romero K, Heise CW, Gallo T, Woosley, RD.  QTFactors.org:  A companion database for use with QTdrugs.org, Cardiology Today, June 2018 https://www.healio.com/cardiology/arrhythmia-disorders/news/print/cardiology-today/%7ba8dfc16f-b074-4e54-8e1f-6ec911293957%7d/qtfactorsorg-a-companion-database-for-use-with-qtdrugsorg

2017

Woosley, R.L. Antibiotics, QT prolongation, TdP and Sudden Death:  Fact or Fiction, Cardiology Today, September, 2017 https://goo.gl/zbSjoL

Strauss DG, Vicente J, Johannesen L, Blinova K, Mason JW, Weeke P, Behr ER, Roden DM, Woosley R, Kosova G, Rosenberg MA, Newton-Cheh C.  A common genetic variant risk score is associated with drug-induce QT prolongation and torsades de pointes risk: A pilot study.  Circulation 2017 Apr 4; 135(14):1300-1310.

Woosley RL, Romero K, Heise CW, Gallo T, Tate J, Woosley RD, Ward S.  Adverse Drug Event Causality Analysis (ADECA);  A procoess for evalutating evidence and assigning drugs to risk categories for sudden death.  Drug Safety. 2017 40(6): 465-474.

Woosley RL, Schwartz PJ.  Counterfiet drugs:  A plot worthy of John le Carré.  Int. J. Cardiol. 2017 Jun 18. pii: S0167-5273(17)32795-X. doi: 10.1016/j.ijcard.2017.06.016

2016

Lorberbaum T, Sampson KJ, Chang JB, Iyer V, Woosley RL, Kass RS et al. Coupling Data Mining and Laboratory Experiments to Discover Drug Interactions Causing QT Prolongation.  J Am Coll Cardiol 2016; 68(16):1756-1764.

Lorberbaum T, Sampson KJ, Woosley RL, Kass RS, Tatonetti NP. An Integrative Data Science Pipeline to Identify Novel Drug Interactions that Prolong the QT Interval. Drug Saf 2016.

Woosley R. Potent Inhibition of hERG Channels by the Over-the-Counter Antidiarrheal Agent Loperamide. PracticeUpdate website. Available at: http://www.practiceupdate.com/content/causal-association-suggested-between-loperamide-and-torsades-de-pointes/44177/65/2/1. Accessed October 07, 2016 

Schwartz P and Woosley RL, Predicting the Unpredictable:  Drug-induced QT prolongation and torsades de pointes.  J. Amer. Coll. Card. Vol. 67, No. 13, 2016 http://dx.doi.org/10.1016/j.jacc.2015.12.063 

Woosley R. Macrolide Antibiotics and the Risk of Ventricular Arrhythmia in Older Adults. PracticeUpdate website. Available at: http://www.practiceupdate.com/content/macrolide-antibiotics-and-ventricular-arrhythmia-in-older-adults/35920/65/2/1. Accessed April 27, 2016

2015

Vicente J, Simlund J, Johannesen L, et al. Investigation of potential mechanisms of sex differences in quinidine-induced torsade de pointes risk. J Electrocardiol 2015; 48:533-8.

Woosley RL, Whyte J, Mohamadi A, Romero K. "Medical Decision Support Systems and Therapeutics - The Role of Auto-Pilots". Clin Pharmacol Ther 2015.

2014

Woosley RL. An interview with Raymond L. Woosley, Trends Pharmacol Sci 2014; 35:305-7.

Postema PG and Woosley RL, Use of drugs in Long QT Syndrome Type 3 and Brugada Syndrome, Cardiac Sodium Channel Disorders, Editor H. Abriel, Cardiology Electrophysiology Clinics, Dec. 2014, Vol. 6 (4).

 

2013

RL Woosley, K. Romero. Assessing cardiovascular drug safety for clinical decision-making. Nat Rev Cardiol. 2013 Jun;10(6):330-7. doi: 10.1038/nrcardio.2013.57. Epub 2013 Apr 16.  PMID: 23591268

Pieter G. Postema; Jon Neville; Jonas S.S.G. de Jong; Klaus Romero; Arthur A.M. Wilde; Raymond L. Woosley.Safe drug use in long QT syndrome and Brugada syndrome: comparison of website statistics.  Europace 2013; doi: 10.1093/europace/eut018.  PMID: 23533266

Woosley RL. It is important research, but why is it necessary?  Clin Pharmacol Ther. 2013 Apr;93(4):297-9. doi: 10.1038/clpt.2013.15.  PMID:  23511783

Lindor RA, Allocco SJ, Cheatham L, Cortese DA, Hall RF, Mangold WJ Jr, Pizziconi V, Poste G, Quinn B, Roth M, Saks MJ, Wassman ER, Woosley RL, Marchant GE.  Regulatory and reimbursement innovation.  Sci Transl Med. 2013 Mar 13;5(176):176cm3. doi: 10.1126/scitranslmed.3005437.  PMID: 23486776

Woosley RL.  One hundred years of drug regulation: where do we go from here?  Annu Rev Pharmacol Toxicol. 2013;53:255-73. doi: 10.1146/annurev-pharmtox-011112-140159. Epub 2012 Oct 16.  PMID:  23072378

2012

Hines LE, Malone DC, Murphy JE. Recommendations for generating, evaluating,and implementing drug-drug interaction evidence. Pharmacotherapy. 2012 Apr;32(4):304-13.

Woosley RL. Is it possible for FDA regulatory scientists and industry scientists to work together? Clin Pharmacol Ther. 2012 Mar;91(3):390-2.

2011

McClellan M, Benner J, Schilsky R, Epstein D, Woosley R, Friend S, Sidransky
D, Geoghegan C, Kessler D. An accelerated pathway for targeted cancer therapies. Nat Rev Drug Discov. 2011 Feb;10(2):79-80..

Hines LE, Murphy JE, Grizzle AJ, Malone DM. Critical Issues Associated with Drug-Drug Interactions: Highlights from A MultiStakeholder Conference. American Journal of Health-System Pharmacy. 2011 May 15;68(10):941-6.

Warholak T, Hines L, Saverno KR, Grizzle A, Malone D. An Assessment Tool for Pharmacy Drug-Drug Interaction Software. Journal of the American Pharmacists Association. 2011 May-Jun;51(3):418-24.

Higgins L, Brown M, Murphy JE, Malone DC, Armstrong EP, Woosley RL. Community pharmacy and pharmacist-staff call center assessment of medication safety and effectiveness; a feasibility study. J Am Pharm Assoc (2003). 2011 Jan-Feb;51(1):82-9.

Lisa E. Hines, Diana Ceron-Cabrera, Klaus Romero, Marietta Anthony, Raymond L. Woosley, Edward P. Armstrong, Daniel C. Malone. Evaluation of Warfarin Drug Interaction Listings in US Product Labeling for Warfarin and Interacting Drugs. Clinical Therapeutics Journal. 2011 Jan;33(1):36-45.

2010

Kim R Saverno, Lisa E Hines, Terri L Warholak, Amy J Grizzle, Lauren Babits, Courtney Clark, Ann M Taylor, Daniel C Malone. Ability of pharmacy clinical decision-support software to alert users about clinically important drug-drug interactions. JAMIA 2011;18:32-37 2011 Jan 1;18(1):32-7. Epub 2010 Dec 3.

Warholak T, Menke JM, Hines LE, Sherrill D, Reel S, Murphy J, Malone DC. A Drug-Drug Interaction Knowledge Assessment Instrument for Health Professional Students: A Rasch Analysis of Validity Evidence. Research in Social and Administrative Pharmacy, 2011 Mar;7(1):16-26. Epub 2010 Apr 10.

IOM (Institute of Medicine). 2010. Women's Health Research: Progress, Pitfalls, and Promise. Washington, DC: The National Academies Press.

Warholak TL, Menke M, Hines LE, Reel S, Murphy J, Sherril D, Malone DC. A drug-drug knowledge assessment instrument for health professional students: A Rasch analysis of validity evidence. Res Social Adm Pharm. 2010. April [Epub]

Olvey EL, Clauschee S, Malone DC. Comparison of critical drug-drug interaction listings: the Department of Veterans Affairs medical system and standard reference compendia. Clin Pharmacol Ther. 2010;87(1):48-51. 

2009

Babits L, Clark C, Warholak T, Hines LE, Menke JM, Malone DC. Evaluation of Pharmacy Software Programs to Detect Clinically Important Drug-Drug Interactions. Journal of the American Pharmacists Association. 2009; 49(2): 294.

Woosley RL, Romero K. Time to Replace Bazett's QT-Correction. Pacing Clin Electrophysiology.2009; volume 32 Issue 11,1379 - 380

Warholak TL, McCulloch M, Bamgart A, Smith M, Fink W, Fritz W. An Exploratory Comparison of Medication Lists at Hospital Admission with Administrative Database Records. Journal of Managed Care Pharmacy. 2009;15(9):751-58.

Murphy JE, Malone DC, Olson BM, Grizzle AJ, Armstrong EP, Skrepnek GH. Development of computerized alerts with management strategies for 25 serious drug-drug interactions. Am J Health Syst Pharm. 2009;66(1):38-44.

Anthony M, Romero K, Malone DC, Hines LE, Higgins L, Woosley RL. Warfarin interactions with substances listed in drug information compendia and in the FDA-approved label for warfarin sodium. Clin Pharmacol Ther. 2009;86(4):425-9

Saverno KR, Malone DC, Kurowsky J. Pharmacy students' ability to identify potential drug-drug interactions. Am J Pharm Educ. 2009;73(2): 27

R.Woosley, K Romero. 'Drugs that prolong the QT interval'. June 2009. http://cme.medscape.com/viewarticle/704202

2008

Anthony M, Lee KY, Bertram CT, Abarca J, Rehfeld RA, Malone DC, Freeman M, Woosley RL. Gender and age differences in medications dispensed from a national chain drugstore. Journal of Women's Health (Larchmt.) 2008; 17(5):735-743.

Ko Y, Malone DC, Skrepnek GH, Armstrong EP, Murphy JE, Abarca J, Rehfeld RA, Reel SJ, Woosley RL. Prescribers' knowledge of and sources of information for potential drug-drug interactions: a postal survey of US prescribers. Drug Safety 2008; 31(6):525-536.

2007

Grizzle AJ, Mahmood MH, Ko Y, Murphy JE, Armstrong EP, Skrepnek GH, Jones WN, Schepers GP, Nichol WP, Houranieh A, Dare DC, Hoey CT, Malone DC. Reasons provided by prescribers when overriding drug-drug interaction alerts. The American Journal of Managed Care 2007; 13(10):573-578

Ko Y, Abarca J, Malone DC, Dare DC, Geraets D, Houranieh A, Jones WN, Nichol WP, Schepers GP, Wilhardt M. Practitioners' views on computerized drug-drug interaction alerts in the VA system. Journal of the American Medical Informatics Association 2007; 14(1):56-64

Mahmood M, Malone DC, Skrepnek GH, Abarca J, Armstrong EP, Murphy JE, Grizzle AJ, Ko Y, Woosley RL. Potential drug-drug interactions within Veterans Affairs
medical centers. American Journal of Health-System Pharmacy 2007; 64(14):1500-1505

Malone DC, Abarca J, Skrepnek GH, Murphy JE, Armstrong EP, Grizzle AJ, Rehfeld RA, Woosley RL. Pharmacist workload and pharmacy characteristics associated with
the dispensing of potentially clinically important drug-drug interactions. Medical Care 2007; 45(5):456-462

Shin JG, Kang WK, Shon JH, Arefayene M, Yoon YR, Kim KA, Kim DI, Kim DS, Cho KH, Woosley RL, Flockhart DA. Possible interethnic differences in quinidine-induced
QT prolongation between healthy Caucasian and Korean subjects. British Journal of Clinical Pharmacology 2007; 63(2):206-215

2006

Abarca J, Colon LR, Wang VS, Malone DC, Murphy JE, Armstrong EP. Evaluation of the performance of drug-drug interaction screening software in community and hospital pharmacies. Journal of Managed Care Pharmacy 2006;12(5):383-389.

Abarca J, Malone DC, Skrepnek G, Rehfeld R, Murphy JE, Grizzle AJ, Armstrong EP, Woosley RL. Community pharmacy managers’ perception of computerized drug-drug interaction alerts. Journal of the American Pharmacists Association 2006; 46(2):148-153.

Brown M, Frost R, Ko Y, Woosley RL. Diagramming patients’ views of root causes of adverse drug events in ambulatory care: An online tool for planning education and research. Patient Education and Counseling 2006; 62(3):305-315. Epub 2006 Jul 31.

Indik JH, Pearson EC, Fried K, Woosley RL. Bazett and Fridericia QT correction formulas interfere with measurement of drug-induced changes in QT interval. Heart Rhythm 2006; 3(9):1003-1007.

Johnson L, Strich H, Taylor A, Timmermann B, Malone D, Teufel-Shone N, Drummond R, Woosley R, Pereira E, Martinez A. Use of herbal remedies by diabetic Hispanic women in the southwestern United States. Phytotherapy Research 2006; 20(4):250-255.

Katchman AN, Koerner J, Tosaka T, Woosley RL, Ebert SN. Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and non-torsadogenic drugs. Journal of Pharmacology And Experimental Therapeutics 2006; 316(3):1098-1106. Epub 2005 Nov 8.

Ko Y, Brown M, Frost R, Woosley RL. Development of a prescription medication information webliography for consumers. Journal of General Internal Medicine 2006; Dec; 21(12):1313-6. Epub 2006 Sep 25

Murphy JE, Malone DC, Skrepnek GH, Armstrong EP, Abarca J, Grizzle A, Rehfeld R, Woosley RL. The role of technicians in the management of computerized drug-drug interaction alerts in community pharmacies. Journal of Pharmacy Technology 2006;22:155-160.

Perkins NA, Murphy JE, Malone DC, Armstrong EP. Performance of drug-drug interaction software for personal digital assistants. The Annals of Pharmacotherapy 2006; 40(5):850-855. Epub 2006 Apr 18.

Skrepnek GH, Armstrong EP, Malone DC, Abarca J, Murphy JE, Grizzle AJ, Rehfeld R, Woosley RL. Workload and availability of technology in metropolitan community pharmacies. Journal of the American Pharmacists Association 2006; 46(2):154-160.

2005

Malone DC, Hutchins DS, Haupert H, Hansten P, Duncan B, Van Bergen RC, Solomon SL, Lipton RB. Assessment of potential drug-drug interactions with a prescription claims database. American Journal of Health-System Pharmacy 2005; 62(19):1983-1991.

Pearson EC, Woosley RL. QT prolongation and torsades de pointes among methadone users: reports to the FDA spontaneous reporting system. Pharmacoepidemiology and Drug Safety 2005;14(11):747-753.

Skrepnek GH, Abarca J, Malone DC, Armstrong EP, Shirazi FM, Woosley RL. Incremental effects of concurrent pharmacotherapeutic regimens for heart failure on hospitalizations and costs. The Annals of Pharmacotherapy 2005; 39(11):1785-1791. 

2004

Abarca J, Malone DC, Armstrong EP, Grizzle AJ, Hansten PD, Van Bergen RC, Lipton RB. Concordance of severity ratings provided in four drug interaction compendia. Journal of the American Pharmacists Association(2003) 2004; 44(2):136-14

Curtis LH, Law AW, Anstrom KJ, Schulman KA. Insurance effect on prescription drug expenditures among the elderly: findings from the 1997 medical expenditure panel survey. Medical Care. 2004;42(5):439-446.

Curtis LH, Ostbye T, Sendersky V, Hutchison S, Dans PE, Wright A, Woosley RL, Schulman KA. Inappropriate prescribing for elderly Americans in a large outpatient population. Archives of Internal Medicine 2004;164(15):1621-1625.

Malone DC, Abarca J, Hansten PD, Grizzle AJ, Armstrong EP, Van Bergen RC, Duncan-Edgar BS, Solomon SL, Lipton RB. Identification of serious drug-drug interactions: results of the partnership to prevent drug-drug interactions. Journal of the American Pharmacists Association (Wash DC ) 2004; 44(2):142-151.

Murphy JE, Forrey RA, Desiraju U. Community pharmacists' responses to drug-drug interaction alerts. American Journal of Health-System Pharmacy 2004; 61(14):1484-1487

Woosley RL. Discovering adverse reactions: why does it take so long? Clinical Pharmacology and Therapeutics 2004; 76(4):287-289

2003

Kornick CA, Kilborn MJ, Santiago-Palma J, Keefe DL, Katchman AN, Schulman G, Ebert SN, Woosley RL, Payne R, Manfredi PL. QTc interval prolongation associated with intravenous methadone. Pain 2003;105(3):499-506.

Liu X, Katchman A, Whitfield BH, Wan G, Janowski EM, Woosley RL, Ebert SN. In vivo androgen treatment shortens the QT interval and increases the destinies of IKr and of IK1 repolarizing potassium currents in orchiectomized male rabbits. Cardiovascular Research 2003;57(1):28-36.

2002

Flockhart DA, Yasuda SU, Pezzullo JC, Knollmann BC. Teaching rational prescribing: a new clinical pharmacology curriculum for medical schools. Naunyn-Schmiedeberg's Archives of Pharmacology 2002; 366:33-43

Katchman AN, McGroary KA, Kilborn MJ, Kornick CA, Manfredi PL, Woosley RL, Ebert SN, Influence of Opioid Agonists on Cardiac Human Ether-a-go-go related Gene K+ Currents. The Journal of Pharmacology and Experimental Therapeutics 2002; 303:688-694

Katchman AN, Woosley RL, Ebert SN. Comparative evaluation of opioid agonists on HERG K+ current. World Congress of Pharmacology 2002; July

Rosebraugh CJ, Honig PK, Yasuda SU, Pezzullo JC, Woosley RL. Centers for Education and Research on Therapeutics report: Survey of medication errors education during undergraduate and graduate medical education in the United States. Clinical Pharmacology and Therapeutics 2002; 71:4-10

Yasuda SU, Zannikos P, Young AE, Fried KM, Wainer IW, Woosley RL. The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine. British Journal of Clinical Pharmacology 2002; 53:519-525 

2001

Desta Z, Soukhova N, Flockhart DA. Inhibition of cytochrome P450 (CYP450) isoforms by isoniazid: Potent inhibition of CYP2C19 and CYP3A. Antimicrobial Agents and Chemotherapyr 2001;45:382-392

Desta Z, Soukhova N, Morocho AM, Flockhart DA. Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: major role in CYP3A. Journal of Pharmacology and Experimental Therapeutics 2001; 298(2):508-520.

Katchman AN, Ebert SN, McCroary KA, Woosley RL. Methadone blocks HERG current in transfected HEK cells. Pharmacologist 2001;43:98

Kilborn MJ, Woosley RL. Registry for torsades de pointes with drug treatment exists. British Medical Journal 2001; 322:672

Remich SA, Kilborn MJ, Woosley RL. The role of internet-based registries in tandem with genetic screening for the study of drug-induced arrhythmias. Current Therapeutic Research 2001;62:787-795

Rodriguez I, Kilborn MJ, Liu XK, Pezzullo JC, Woosley RL. Drug-induced QT prolongation in women during the menstrual cycle. Journal of the American Medical Association 2001;285:1322-26.

Rosebraugh CJ, Flockhart DA, Yasuda SU, Woosley RL. Visual hallucination and tremor induced by sertraline and oxycodone in a bone marrow transplant patient. Journal of Clinical Pharmacology 2001; 41:224-27.

Rosebraugh CJ, Honig PK, Yasuda SU, Pezzullo JC, Flockhart DA, Woosley RL. Formal education about medication errors in internal medicine clerkships. Journal of the American Medical Association 2001;286:1019-20. 

2000

Benton Re, Sale M, Flockhart DA, Woosley RL. Greater quinidine-induced QTc interval prolongation in women. Clinical Pharmacology and Therapeutics 2000; 674:413-418

Desta Z, Soukhouva N, Morocho A, Park J, Mahal SK, Flockhart DA. Stereoselective determination of cisapride, a prokinetic agent, in human plasma by chiral high-performance liquid chromatography with ultraviolet detection: application to pharmacokinetic study. Journal of Chromatography B: Biomedical Sciences and Applications 2000;744:263-272

Flockhart DA, Desta Z, Mahal SK. Selection of drugs to treat gastro-oesophageal reflux disease: the role of drug interactions. Clinical Pharmacokinetics 2000; 39:295-309.

Flockhart DA, Oesterheld JO. Cytochrome P450-mediated drug interactions. Child and Adolescent Psychiatry Clinics of North America 2000; 9(1):43-76.

Wesche DL, Schuster BG, Wang WX, Woosley RL. Mechanism of cardiotoxicity of halofantrine. Clinical Pharmacology and Therapeutics 2000; 67:521-529