QTFactors.org - Clinical Factors Associated with Prolonged QTc and/or TdP: This is a list of clinical factors that have been associated in the medical literature with prolonged QTc and/or Torsades de Pointes (TdP).
CredibleMeds® has developed Adverse Drug Event Causality Analysis (ADECA©), a systematic approach based on the Bradford Hill criteria for assigning causality for drugs and adverse events. Click here to see a detailed description.
How do I cite the QTdrugs lists on the CredibleMeds.org website in a scientific publication?
Electronic Citation: Woosley, RL, Heise, CW and Romero, KA, www.Crediblemeds.org, QTdrugs List, Accession Date, AZCERT, Inc. 1822 Innovation Park Dr., Oro Valley, AZ 85755
Click here to read how our CredibleCDS™ uses the CredibleMeds® QTdrugs lists to alert physicians when their patients are at increased risk of sudden death.
Straus et al. extracted a list of non-cardiac drugs that prolong QT from the CredibleMeds.org website in order to examine all-cause mortality in a population-based, case–control study. They found an approximately threefold greater risk of death (95% CI 1.6–4.7) among patients who had been treated with the non-cardiac, QT-prolonging drugs listed in the CredibleMeds.org database. On the basis of this analysis, the investigators estimated that the use of these drugs causes >15,000 deaths annually in the USA and Europe. Click here for PubMed Abstract.
van der Sijs and colleagues investigated whether physicians who had prescribed two drugs from the CredibleMeds.org lists and then ignored a drug-QTDrug interaction alert for QT prolongation, subsequently ordered an ECG for the patient. The researchers found that 33% of patients did not have an ECG; however excessive QT prolongation (>75 ms increase) was seen in 31% of those who did have an ECG. In their report, van der Sijs et al. cite the importance of the CredibleMeds.org lists for their drug safety program and pharmacovigilance efforts. Click here for PubMed Abstract.
How are the QTdrugs lists being used as references for Optimal Prescribing?
The Medical Letter and major textbooks of medicine cite the QTdrugs lists as resources for prescribers when making prescribing decisions.
New Zealand's federal Medicines Safety Authority cites the QTdrugs.org lists that are maintained on CredibleMeds.org as resources for the Authority’s evaluation of the safety of anti-depressants that prolong the QT interval. Click here for a sample report.